Epigenetics and Maternal Behavior

Science Magazine published an intriguing article overviewing multiple scientists' research on the relationship epigenetics has on maternal behavior in rats (Miller, 2010). This article expands on various topics and thus will be investigated in part this week, and then again next week. The article begins by exploring the research done by Michael Meaney and Moshe Szyf, published in Nature Neuroscience (Weaver, 2004). Rats vary in ways they nurture their pups - some mothers provide easy accessibility to milk and groom their young frequently, and other mothers do not spend as much time with their pups. Rats interactions between pups and their mothers were monitored. Scientist Michael Meaney determined in 2004 that, after various stress inducing tests, pups raised by mothers that provided less nurturing did not respond to stress as well as the others (For example exhibited a surge of cortisone when the rat was placed in a confining tube).

Meaney concluded that this stress sensitivity was because of a reduction in glucocorticoid receptors caused by DNA methylation of a particular gene. Methyl groups on a particular site blocked the transcription of the gene and thus production of more receptors could not be achieved.

Therefore, neglectful maternal care resulted in specific alterations in receptors that were involved in response to stress, affecting genes in a long term way. Maternal neglect caused changes in gene expression that made offspring anxious and worse at handling stressful situations.

It is difficult to grasp that the innocent rat pup's genetics were physically altered by less frequent parenting behavior, and this caused neurological differences compared to the other pups. With such a dramatic outcome, could it be possible to reverse the affects the mother rats instilled on their pups? Science Magazine claims, "Subsequent experiments showed that enzymes that reverse DNA methylation of the glucocorticoid receptor gene also reverse the effects of unenthusiastic mothering on the offspring’s hormonal and behavioral responses to stress" (Miller, 2010, pg. 25). Reversal due to particular enzymes proves to be a promising future for the rat pups. If it is possible that maternal behavior neurologically affects the rat pups, could it be that this occurs in human children as well? (Figure 1). While this has not been studied as in depth as in rats, these findings may play a key role in the pharmaceutical industry and our understanding of drugs. This topic is also discussed in Science Magazine's article and will be explored more next week. 

(Figure 1. Adapted from "The Seductive Allure of Behavioral Epigenetics" by G. Miller, 2010, Science Magazine, 329 (5987), 25) 

Reference:

Miller, G. (2010). The Seductive Allure of Behavioral Epigenetics. Science Magazine, 329 (5987), 24-27. doi: 10.1126/science.329.5987.24

Weaver IC, C. N., Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. (2004). Epigenetic Programming by Maternal Behavior. Nature Neuroscience, 7(8), 847-854. 

Pictures: [From top to bottom of entry] All accessed 22/03/2015.

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http://www.visembryo.com/images/rat%20mother%20and%20pups.jpg

"The Seductive Allure of Behavioral Epigenetics" by G. Miller, 2010, Science Magazine, 329 (5987), 25